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totally agree!  If I'm training for a longer race, I will still get my pedicures, but I ask them to leave the calluses instead of scraping that dead tough skin away.  It protects your foot, and will prevent  blisters.  I value that you are a dude, and care enough about your hygeine to get a pedicure - Girls really do appreciate that.  However, keep it rough to keep your run safe.

Happy Running!

IMO the real question is why those calluses are there.. You might  need to size up your shoes, pick a different shoe width,  or check for  excess foot motion with a treadmill running analysis at your local PT or  running store.

I agree with the others that callus is  your friend for longer runs. Mine build up as I train for distance  events like the marathon, but I haven't had blisters in years. They  usually come before callus, or if you change to unfamiliar shoes, socks  too thick, etc. Regarding socks, there are thin double-lined socks that  reduce blistering at running stores.

Nevertheless, I  know a runner who competes in 80-100 races a year. He always brings an  exfoliating tool to work on the calluses of his feet before races. Go figure...

Another  thing you might try is to abandon shoes altogether for the Vibram "Five  finger" foot gloves, which let your toes spread naturally instead of  cramping them into the average toe box. Most people do not like running  in them, but if blisters and calluses are dogging your dogs, it's worth a shot.