Zenit will be looking to recover their form after a stunning 3-0 loss in Malaga on matchday one, and they continue without playmaker Danny, who remains a long-term casualty after suffering knee ligament damage in December of last year.
Axel Witsel, the expensive summer arrival from Benfica, is battling to be fit to make his European bow for the Russian giants, while Sergei Semak and Tomas Hubocan are also rated as touch and go to be considered for a starting berth.
Igor Denisov and Alexander Kerzhakov, who were recently jettisoned to the reserves for outspoken remarks regarding the acquisitions of Hulk and Witsel on significant salaries, are in contention to return to the side, with the latter appearing from the bench in the weekend draw with Lokomotiv Moscow.
The injury-plagued Alexandre Pato remains out of action for AC Milan, as they look to breathe some life into their dwindling campaign, while Sulley Muntari and Mathieu Flamini are also doubts.
With Milan drawing against Anderlecht on Matchday 1, a positive result for Massimiliano Allegri's side is imperative, particularly with the derby against neighbours Inter to come on Sunday.