Schalke boss Huub Stevens has a couple of selection headaches going into the clash with the French champions. At the back, Joel Matip should keep his place at the heart of defence after scoring an excellent header against Fortuna Dusseldorf, despite Atsuto Uchida's return to fitness.
The Cameroon international's presence will mean that Benedikt Howedes will continue in his less-preferred role as a right-back, with Kyriakos Papadopoulos and Christian Fuchs completing the defence. Jermaine Jones is now fully-fit after missing the win over Mainz, and will line up alongside Roman Neustadter in midfield.
However, Jefferson Farfan, who had not recovered sufficiently from strained knee ligaments to feature against his side's Ruhr rivals, is unlikely to be any more than a substitute on Wednesday, leaving Ibrahim Afellay, Lewis Holtby and Julian Draxler to form an attacking trio behind Klaas-Jan Huntelaar, with Tranquillo Barnetta dropping out.
Meanwhile, Rene Girard's main problem area will be defence as the Paillade prepare for the trip to Gelsenkirchen. Cyril Jeunechamp limped out of the weekend's clash with Nancy and is unlikely to recover in time, while Henri Bedimo picked up an injury training.
Their absences may force club captain Mapou Yanga-Mbiwa to act as a makeshift full-back for his side. In midfield, the coach must choose between Marco Estrada and Benjamin Stambouli, and may elect to stick with the former.
Finally, John Utaka is out, leaving Remy Cabella, Younes Belhanda and Karim Ait Fana to form a potent attacking triumvirate behind lone striker Souleymane Camara.