Shox may have some benefits, but they are dangerous
Nike hasn't had a good running shoe line for a number of years. Some shoes fit some runners and are ok, but unfortunately for those of us that used to be diehard Nike fans, its just not there anymore.
Remember, a shoe is design for a specific foot, so make sure you're in one that works for you. If you're in MA check out Marathon Sports for help. they are usually great there, though it may cost you a little more. They'll also suggest you take them out for a run around the block before you buy them!
For the best overall shoe company, I have to give it to Asics. They have shoes for everyone and there 2000 and 1000 series are great 'I don't know anything about shoes' shoes. I've been in the DS Trainer for many years, but they narrowed the toebox on the new model and it doesn't work for me anymore. All three are great shoes in my mind (DS only for efficient runners, with few injuries and no overpronation, and only good for 300-500 miles).