It might not kill you, but I would certainly be extremely unhappy to run without having had water for a while and not being able to have water for several more hours.
Besides which, and I mean this with all respect, if you're trying to get a run in, you're missing the point of the fasting in the first place. The symbolism of Yom Kippur, besides the idea of fasting for repentance, is that we are supposed to behave as if we are DEAD and being judged. The dead do not eat, drink, or have any comforts (bathing, perfume, leather shoes), and they certainly don't run. What is the purpose of your fast if it's not going to lead you to the spiritual dimension of the holy day and it's just another day to squeeze in a run?