clean the area very well with an alcohol pad.
this not only reduces the likelihood of infection, but it also makes the dressings adhere to the skin better.
drain the blister on the edge with a sterile pin
put a piece of spenco 2nd skin on top (don't forget to remove the two peices of backing.
put a piece of mole skin over the 2nd skin.
if it's in a high friction area, put a single layer of duct tape over the moleskin.
If you can find it, use Blist-o-Ban, by SAM Medical. It's very hard to find, but the best product on the market for blisters.
Maybe get a double layer sock at your running store.
If you can figure out where the seam in the shoe is, consider doing this.
Take a screwdriver that has a nice smooth (not gouged or beaten up) rounded handle base. Put the screw driver in a vise so the handle is pointing up. Put your shoe over the screw driver handle and rub it back and forth with a fair amount of pressure over the bad seam. This should soften it up quite a bit.
http://This message has been edited by littlewaywelt (edited May-04-2007).