Go at the hitter and get him out. Who cares if he drives in a run. It will only be 2-1. Don't put him on base. He's the tying run. Then one hit can tie the game.

This isn't strangers in the night. In pro ball it isn't even about what happened earlier in the game. The pros have a significant amount of detail on hitter vs. pitcher that assists them in their decisions.

Barry Bonds got an IW with the bases loaded because the odds were in favor of it minimizing how many runs would score in the inning (his walk plus what would happen next).

I would just go after him and get him out.  Keep the pitches low.  You're ahead 2, so get him to pop up or ground out.  Odds are in your favor as a pitcher.