I'm bumping this ancient thread because there aren't too many barefoot threads around.
I recently started reading some of this barefoot running stuff, and the book "Born to Run" by Chris McDougall, and I have owned a pair of vibram fivefingers for a few years. So, I gave it a try...
Running barefoot (or with minimal footwear) is GREAT! I'm a slowpoke normally, (10:00 to 10:20 or so per mile), but my first run with the VFFs was 9:30 per mile! It is really noticeable how little mass is on your feet with VFFs. I stupidly did 3.1 miles on my first run with them... and blistered my feet in a few places, and I'm still fighting that issue, but the callouses are coming in nicely. I've done six runs so far in them, and really like it. I have always had crazy strong calves (like an upside down Popeye), so I may have an advantage, but I'd like to encourage folks to read more about it, and maybe give it a try. I expected it to be hellish, but it is really fun... just go short on the first few!