For us heavier riders, yes.
I'm not saying I never have to stand, because I do depending on the length and grade of the climb. Short steep hills, I stand. Long, less steep climbs, I'm seated. Long, steep climbs, I find another route. (no, really I drop to granny gear and gut it out).
In general, having a higher cadence (lower gear) and staying in the saddle will stress the legs less because you are not having to support your weight in addition to pedaling. In addition, you can pull on the up stroke of the pedaling cycle which is a technique that definately takes time to develop. To get the feel, unclip one shoe and pedal with one leg concentrating on the up stroke and pushing your heel down just as the pedal travels over the top. When the pedal is almost to the bottom, think of scraping mud off the bottom of your shoe and continue pulling all the way to the top again.
Do this for a few minutes, then switch to the other side. You'll need cycling shoes if you don't have them already and do this on level ground to begin. Then work on it with both shoes clipped in for long periods while riding on flat roads. Once you have the technique down head for the hills, scoot back on your saddle an inch or so and surprise yourself.
When you need to stand, you won't be as effective on the upstroke but it definately helps. Modify the technique just a bit by pointing your toes down through the entire revolution of the crank.
Remember, as your heartrate and breathing increase, don't gasp for air, concentrate on "belly-breathing" using your diaphragm and ab muscles to expand the lungs as you breath deeply in through your nose and exhale through your mouth. Pursing your lips and blowing helps me when I'm really exerting myself (think of Lamaze classes for expectant mothers). Odd as it sounds, try to relax as you climb. The more tense you are, the more energy you burn.
I'm no expert, this is just info I have gathered, put into use, and found to work for me.
Have fun and be sure to always wear a helmet.