I've spent a fair bit of time trying out different socks to see what works best for me. So far, I've worn DryMax, Wright Socks, SmartWool, Injinji, and Balega. All of them have been very good, but if I had to pick one right now, I'd probably go with WrightSocks. They seem to have the best balance of performance and price.

They're two-layer socks, so the layers rub together rather than having your skin rub against the sock. The decreased friction reduces the likeilhood of blisters forming. I think they were about $7-10 per pair, which is a lower price point than any of the others (from what I recall).

I've run some tough races with my DryMax socks, and they've been excellent. They're similar to the WrightSocks, but they tend to be thicker. (I ran my races in either the DryMax Maximum Protection or Trail socks, which are designed to be a little thicker. I don't have experience with other DryMax models.) It's also possible that there are thicker versions of the WrightSocks that I haven't tried.

The Injinji socks are also nice, though it takes some getting used to having your toes separated (think in terms of gloves for your feet). I haven't run in the Balegas enough to form a solid opinion, though they seem nice so far.

The SmartWool socks are nice, but I definitely tend to prefer the technical fabrics for races. I pretty much use the SmartWools for training runs; I did wear a pair for one race and ended up with some horrible blisters. I'm not ready to write them off entirely, though.

I don't know if this rambling post is at all helpful, but those are my unscientific impressions. Good luck on your sock-quest!

Don

Hey Derek,

First, welcome to a whole new world!  Running isn't just putting on some old shoes, and heading out the door anymore:)  There are a lot of choices out there to keep you healthy and enjoying running.  I've only been running for about 2 years now,(did two 1/2 marathons last year, and training for the full this year) and have never been a "runner" before... but I definitely love it.  The socks, shoes, clothing make such a difference.  Here's what I've found over the past few years.

• WrightSock - by far my favorite for distance running. Cool Mesh Double Layer is the one I use.  With the double layer, it prevents blisters and is a lighter sock. We just ran 18 miles on Sat. and I didn't have a single blister or hotspot.  They do have different versions now, and check out their website.  They are pretty thin, so I am going to try the more cushioned ones as soon as I can find them in town (or I'll just order them online)  Great price for what they offer. I also have one of their SLR pair (Single Layer Running) and it's great for shorter distances and provides more cushioning.
• Balega - great for everyday workouts. I use these for 3-5 mile runs and in the gym. Lighter mesh top.  Next to the CoolMesh WrightSock, I use the Balega's 2nd in my lineup.
• Feetures - a good all around running sock.  Average price, and decent cushion.  Snug around the mid-foot, and they also offer a thin version.

Good luck with "trying" out a few different types of socks. You're already on the right track by using a performance sock vs. old cotton!  The best thing to do is try a few, find what works best for you and your shoe.  It's an investment, and I thought it was crazy to spend $11 on a pair of socks at first, but now, I can't wait to try new socks!  Also, I always wash my socks inside out, and hang dry... don't use fabric softeners or dry on high heat.

Happy Running!

Brian

(training for San Antonio RnR Marathon)

I recently got a pair of Wrightsock Cool Mesh, and they're great -- the double layer helps reduce friction and they have a pleasant, plush feeling.  I like to wear them for long runs and races.

But for everyday training, I've had very good results with Nike DriFit socks.  They come in a number of different configurations (no-show, low-cut, 1/4, etc.) so you can pick your pleasure, and they're cheap: $4-6 dollars a pair, depending on the exact sock, how many you buy, etc.  The fabric is comfy and friction-free.  They'll start to pill after many, many times through the washer, but otherwise are pretty durable.